Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)–mediated inhibition of platelet production

5 Jun 2012

Abstract excerpt

Proplatelet production represents a terminal stage of megakaryocyte development during which long, branching processes composed of platelet-sized swellings are extended and released into the surrounding culture. Whereas the cytoskeletal mechanics driving these transformations have been the focus of many studies, significant limitations in our ability to quantify the rate and extent of proplatelet production have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heparin-Induced Thrombocytopenia and Thrombosis
Share to Monoclonal and Polyclonal Antibodies Research
Share to Platelet Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22665936
DOI: 10.1182/blood-2012-04-420968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)–mediated inhibition of platelet productionPMID 22665936Read ↗

A circle of life: platelet and megakaryocyte cytoskeleton dynamics in health and disease.Semantic proximity Read ↗

Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formationSemantic proximity Read ↗

Cell cycle–dependent centrosome clustering precedes proplatelet formationSemantic proximity Read ↗

Post-translational polymodification of <i>β</i> 1 tubulin regulates motor protein localisation in platelet production and functionSemantic proximity Read ↗

Timelapse viability assay to detect division and death of primary multiple myeloma cells in response to drug treatments with single cell resolutionSemantic proximity Read ↗

Hematopoietic-specific β1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2Semantic proximity Read ↗

Mice Lacking Transcription Factor NF-E2 Provide In Vivo Validation of the Proplatelet Model of Thrombocytopoiesis and Show a Platelet Production Defect That Is Intrinsic to MegakaryocytesSemantic proximity Read ↗

New insights into cytoskeletal remodeling during platelet productionSemantic proximity Read ↗

Membrane budding is a major mechanism of in vivo platelet biogenesisSemantic proximity Read ↗

Revealing eltrombopag's promotion of human megakaryopoiesis through AKT/ERK-dependent pathway activation.Semantic proximity Read ↗

Establishment and characterization of a new human megakaryoblastic cell line (SET-2) that spontaneously matures to megakaryocytes and produces platelet-like particlesSemantic proximity Read ↗

Similar but distinct: the impact of biomechanical forces and culture age on the production, cargo loading, and biological efficacy of human megakaryocytic extracellular vesicles for applications in cell and gene therapiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.