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Article

Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation

23 Apr 2020

Abstract excerpt

Platelets are produced by bone marrow megakaryocytes through cytoplasmic protrusions, named native proplatelets (nPPT), into blood vessels. Proplatelets also refer to protrusions observed in megakaryocyte culture (cPPT) that are morphologically different. Contrary to cPPT, the mechanisms of nPPT formation are poorly understood. We show here in living mice that nPPT elongation is in equilibrium between protrusive...

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PMID: 32327502
DOI: 10.3324/haematol.2019.239111

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