Article
Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium.
Human genetics - 1 Sept 2012
Verhoeven Virginie J M, Hysi Pirro G, Saw Seang-Mei, Vitart Veronique, Mirshahi Alireza, Guggenheim Jeremy A, Cotch Mary Frances, Yamashiro Kenji, Baird Paul N, Mackey David A, Wojciechowski Robert, Ikram M Kamran, Hewitt Alex W, Duggal Priya, Janmahasatian Sarayut, Khor Chiea-Chuen, Fan Qiao, Zhou Xin, Young Terri L, Tai E-Shyong, Goh Liang-Kee, Li Yi-Ju, Aung Tin, Vithana Eranga, Teo Yik-Ying, Tay Wanting, Sim Xueling, Rudan Igor, Hayward Caroline, Wright Alan F, Polasek Ozren, Campbell Harry, Wilson James F, Fleck Brian W, Nakata Isao, Yoshimura Nagahisa, Yamada Ryo, Matsuda Fumihiko, Ohno-Matsui Kyoko, Nag Abhishek, McMahon George, St Pourcain Beate, Lu Yi, Rahi Jugnoo S, Cumberland Phillippa M, Bhattacharya Shomi, Simpson Claire L, Atwood Larry D, Li Xiaohui, Raffel Leslie J, Murgia Federico, Portas Laura, Despriet Dominiek D G, van Koolwijk Leonieke M E, Wolfram Christian, Lackner Karl J, Tönjes Anke, Mägi Reedik, Lehtimäki Terho, Kähönen Mika, Esko Tõnu, Metspalu Andres, Rantanen Taina, Pärssinen Olavi, Klein Barbara E, Meitinger Thomas, Spector Timothy D, Oostra Ben A, Smith Albert V, de Jong Paulus T V M, Hofman Albert, Amin Najaf, Karssen Lennart C, Rivadeneira Fernando, Vingerling Johannes R, Eiríksdóttir Guðný, Gudnason Vilmundur, Döring Angela, Bettecken Thomas, Uitterlinden André G, Williams Cathy, Zeller Tanja, Castagné Raphaële, Oexle Konrad, van Duijn Cornelia M, Iyengar Sudha K, Mitchell Paul, Wang Jie Jin, Höhn René, Pfeiffer Norbert, Bailey-Wilson Joan E, Stambolian Dwight, Wong Tien-Yin, Hammond Christopher J, Klaver Caroline C W
Abstract excerpt
Myopia is a complex genetic disorder and a common cause of visual impairment among working age adults. Genome-wide association studies have identified susceptibility loci on chromosomes 15q14 and 15q25 in Caucasian populations of European ancestry. Here, we present a confirmation and meta-analysis study in which we assessed whether these two loci are also associated with myopia in other populations. The study...