Article
Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes.
PLoS genetics - 1 Jan 2012
Aubert Geraldine, Baerlocher Gabriela M, Vulto Irma, Poon Steven S, Lansdorp Peter M
Abstract excerpt
Telomerase activity is readily detectable in extracts from human hematopoietic stem and progenitor cells, but appears unable to maintain telomere length with proliferation in vitro and with age in vivo. We performed a detailed study of the telomere length by flow FISH analysis in leukocytes from 835 healthy individuals and 60 individuals with reduced telomerase activity. Healthy individuals showed a broad range...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.