Changing paternal age distribution and the human mutation rate in Europe.

Abstract excerpt

All available evidence indicates that the human mutation rate increases with paternal age. In developed countries, a reduction in the proportion of older parents is a common feature of the marked changes in parental age distribution that occur as a result of family planning. We have related the current paternal age distribution in the European countries for which data is readily available, to a derived curve for...

Topics

• Adult
• Aged
• Europe
• Female
• Gene Frequency
• Humans
• Male
• Maternal Age
• Middle Aged
• Mutation
• Paternal Age
• Pregnancy, High-Risk