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Article

Paternal age and congenital malformations

8 Jul 2005

Abstract excerpt

BACKGROUND: Spontaneous mutations in germ cells increase with male age, but an association between paternal age and congenital malformations is not well established. We conducted a population-based cohort study to estimate this association. METHODS: A study population of couples and their firstborn children were identified in the Danish Fertility Database between 1980 and 1996 (n = 71937). Diagnoses of congenital...

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PMID: 16006461
DOI: 10.1093/humrep/dei186

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