[Analysis of blastomogenic activity of mammal carcinogens in Drosophila using the wts(P4) allele and RNA interference-induced p53 silencing].

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Article

[Analysis of blastomogenic activity of mammal carcinogens in Drosophila using the wts(P4) allele and RNA interference-induced p53 silencing].

Genetika - 1 Apr 2011

Kirsanov K I, Lesovaya E A, Sidorov R A, Belitskiĭ G A, Yakubovskaia M G

Abstract excerpt

The test for somatic mutagenesis and recombination in Drosophila is one of the widely used approaches for determination of possible carcinogenic effects of chemical compounds. The use of heterozygotes for mutant tumor suppressor gene wts enables more direct evaluation of the blastomogenic effects of chemical compounds, by tumor formation in the adult flies. This study presents evaluation of the SMART...

Topics

Alleles
Animals
Biological Assay
Carcinogenicity Tests
Carcinogens
Clone Cells
Drosophila
Drosophila Proteins
Genes, p53
Neoplasms
Protein Kinases
RNA Interference
Sensitivity and Specificity
Warts

Source

Open in PubMed

Identifiers

PMID: 21675235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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