Article
Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity.
Genome research - 1 Oct 2012
Fraser Hunter B, Levy Sasha, Chavan Arun, Shah Hiral B, Perez J Christian, Zhou Yiqi, Siegal Mark L, Sinha Himanshu
Abstract excerpt
The acquisition of new genes, via horizontal transfer or gene duplication/diversification, has been the dominant mechanism thus far implicated in the evolution of microbial pathogenicity. In contrast, the role of many other modes of evolution--such as changes in gene expression regulation-remains unknown. A transition to a pathogenic lifestyle has recently taken place in some lineages of the budding yeast...
Topics
- Adaptation, Biological
- Evolution, Molecular
- Gene Expression Regulation, Fungal
- Genetic Fitness
- Genetic Variation
- Phenotype
- Quantitative Trait Loci
- Regulatory Sequences, Nucleic Acid
- Saccharomyces cerevisiae
- Selection, Genetic