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Article

The spinal muscular atrophy mouse model, SMAΔ7, displays altered axonal transport without global neurofilament alterations.

Acta neuropathologica - 1 Sept 2011

Dale Jeffrey M, Shen Hailian, Barry Devin M, Garcia Virginia B, Rose Ferrill F, Lorson Christian L, Garcia Michael L

Abstract excerpt

Spinal muscular atrophy (SMA) is a neurodegenerative disease resulting from decreased levels of survival motor neuron 1 (SMN1) protein. Reduced SMN1 levels are linked to pathology at neuromuscular junctions (NMJs), which includes decreased vesicle density and organization, decreased quantal release, increased endplate potential duration, and neurofilament (NF) accumulations. This work presents a first study...

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Source

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Identifiers

PMID: 21681521
DOI: 10.1007/s00401-011-0848-5
PMCID: PMC3286646

Genes

SMN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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