Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

β3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cells

28 May 2012

Abstract excerpt

BACKGROUND: The extracellular matrix (ECM) has a key role in facilitating the progression of ovarian cancer and we have shown recently that the secreted ECM protein TGFBI modulates the response of ovarian cancer to paclitaxel-induced cell death. RESULTS: We have determined TGFBI signaling from the extracellular environment is preferential for the cell surface αvß3 integrin heterodimer, in contrast to periostin, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Proteoglycans and glycosaminoglycans research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22640878
DOI: 10.1186/1476-4598-11-36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

β3 integrin modulates transforming growth factor beta induced (TGFBI) function and paclitaxel response in ovarian cancer cellsPMID 22640878Read ↗

Novel prognostic marker TGFBI affects the migration and invasion function of ovarian cancer cells and activates the integrin αvβ3-PI3K-Akt signaling pathwaySemantic proximity Read ↗

TGFBI expression is associated with a better response to chemotherapy in NSCLCSemantic proximity Read ↗

Expression of the type III TGF-β receptor is negatively regulated by TGF-βSemantic proximity Read ↗

β3Integrin and Src facilitate transforming growth factor-β mediated induction of epithelial-mesenchymal transition in mammary epithelial cellsSemantic proximity Read ↗

Suppression of Ovarian Cancer Cell Proliferation is Associated with Upregulation of Cell-Matrix Adhesion Programs and Integrin-β4-Induced Cell Protection from CisplatinSemantic proximity Read ↗

Transforming Growth Factor Beta-Induced (TGFBI) Is an Anti-Adhesive Protein Regulating the Invasive Growth of Melanoma CellsSemantic proximity Read ↗

Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancer.Semantic proximity Read ↗

The balance of cell surface and soluble type III TGF-β receptor regulates BMP signaling in normal and cancerous mammary epithelial cells.Semantic proximity Read ↗

TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cellsSemantic proximity Read ↗

Function and antagonism of beta3 integrins in the development of cancer therapy.Semantic proximity Read ↗

Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-βSemantic proximity Read ↗

Responsiveness to transforming growth factor-beta (TGF-beta)-mediated growth inhibition is a function of membrane-bound TGF-beta type II receptor in human breast cancer cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.