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Article

Distinct roles for long-term hematopoietic stem cells and erythroid precursor cells in a murine model of Jak2V617F-mediated polycythemia vera.

Blood - 5 Jul 2012

Mullally Ann, Poveromo Luke, Schneider Rebekka K, Al-Shahrour Fatima, Lane Steven W, Ebert Benjamin L

Abstract excerpt

In the current model of the pathogenesis of polycythemia vera (PV), the JAK2V617F mutation arises in hematopoietic stem cells (HSCs) that maintain the disease, while erythroid precursor populations expand, resulting in excessive red blood cell production. We examined the role of these specific cell populations using a conditional Jak2V617F knockin murine model. We demonstrate that the most immature long-term (LT)...

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Identifiers

PMID: 22627765
DOI: 10.1182/blood-2012-01-402396
PMCID: PMC3390954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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