Article
Combination of polymorphic variants in serotonin transporter and monoamine oxidase-A genes may influence the risk for early-onset alcoholism.
Psychiatry research - 30 Dec 2012
Bordukalo-Niksic Tatjana, Stefulj Jasminka, Matosic Ana, Mokrovic Gordana, Cicin-Sain Lipa
Abstract excerpt
The combinatory effect of polymorphisms in serotonin transporter and monoamine oxidase-A genes on the aetiopathogenesis of alcoholism was investigated in a sample of 714 individuals. Increased frequency of subjects having three 'suspected' genotypes (5-HTTLPR-LL, STin2-1010 and MAO-A 3-repeat allele) was found among type-2 alcoholic patients (P=0.0189). Results highlight serotonergic/genetic contribution to...
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