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Article

Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.

Cancer research - 1 Dec 2010

Park Jung Wook, Pitot Henry C, Strati Katerina, Spardy Nicole, Duensing Stefan, Grompe Markus, Lambert Paul F

Abstract excerpt

Patients with the rare genetic disease, Fanconi anemia (FA), are highly susceptible to squamous cell carcinomas arising at multiple anatomic sites including the head and neck region. Human papillomaviruses (HPVs), particularly HPV16, are associated with ∼20% of head and neck squamous cell carcinomas (HNSCCs) in the general population. Some but not other investigators have reported that HNSCCs in FA patients are...

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Source

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Identifiers

PMID: 20935219
DOI: 10.1158/0008-5472.CAN-10-1291
PMCID: PMC2999655

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer.PMID 20935219Read ↗

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