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Article

Estimating the genome-wide mutation rate from thousands of unrelated individuals.

American journal of human genetics - 1 Dec 2022

Tian Xiaowen, Cai Ruoyi, Browning Sharon R

Abstract excerpt

We provide a method for estimating the genome-wide mutation rate from sequence data on unrelated individuals by using segments of identity by descent (IBD). The length of an IBD segment indicates the time to shared ancestor of the segment, and mutations that have occurred since the shared ancestor result in discordances between the two IBD haplotypes. Previous methods for IBD-based estimation of mutation rate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36370709
DOI: 10.1016/j.ajhg.2022.10.015
PMCID: PMC9748258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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