Article
Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding.
Cell cycle (Georgetown, Tex.) - 15 Jun 2012
Dastidar Shubhra Ghosh, Lane David P, Verma Chandra S
Abstract excerpt
Why doesn't the F19A mutant of p53 bind to MDM2? Binding thermodynamics have suggested that the loss of packing interactions upon mutating Phe into Ala sidechain results in destabilizing the binding free energy between p53 and MDM2. Does this mutation also modulate the initial recognition between p53 and MDM2? We look at atomistic computer simulations of the process of the initial encounter between wild type p53...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.