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Article

Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations.

PloS one - 1 Jan 2012

Joseph Thomas L, Lane David P, Verma Chandra S

Abstract excerpt

Atomistic simulations of a set of stapled alpha helical peptides derived from the BH3 helix of MCL-1 (Stewart et al. (2010) Nat Chem Biol 6: 595-601) complexed to a fragment (residues 172-320) of MCL-1 revealed that the highest affinity is achieved when the staples engage the surface of MCL-1 as has also been demonstrated for p53-MDM2 (Joseph et al. (2010) Cell Cycle 9: 4560-4568; Baek et al. (2012) J Am Chem Soc...

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Identifiers

PMID: 22952838
DOI: 10.1371/journal.pone.0043985
PMCID: PMC3432064

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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