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Article

Study of MDM2 binding to p53-analogues: affinity, helicity, and applicability to drug design.

Journal of chemical information and modeling - 1 Apr 2009

Kalid Ori, Ben-Tal Nir

Abstract excerpt

MDM2 is a key regulator of the p53 tumor-suppressor protein. Here we study the effect of modifications of a p53 N-terminal fragment on its binding to MDM2, using implicit-solvent MD and MM-GB/SA calculations. We provide interpretation of existing experimental data and predict the effect of mutations on binding. Notably 1) We analyze the effect of regulatory phosphorylations at Ser/Thr residues and suggest that a...

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Source

Identifiers

PMID: 19323449
DOI: 10.1021/ci800352c

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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