Article
Development of a computerized morphometry application for assessment of the tumor fraction in colon carcinoma tissue samples.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2013
Hershkovitz Tova, Shenhav Avshalom, Sabo Edmond, Ben-Izhak Ofer, Hershkovitz Dov
Abstract excerpt
Determining the fraction of tumor cells in colon carcinoma samples analyzed for KRAS mutation status is important for choosing the proper testing modality and accurately interpreting the results. However, when asked to determine the tumor cell fraction in tissue samples, different pathologists give considerably different estimations, possibly leading to erroneous interpretation of KRAS mutation analysis results...
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