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Article

Automated objective determination of percentage of malignant nuclei for mutation testing.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2000

Viray Hollis, Coulter Madeline, Li Kevin, Lane Kristin, Madan Aruna, Mitchell Kisha, Schalper Kurt, Hoyt Clifford, Rimm David L

Abstract excerpt

Detection of DNA mutations in tumor tissue can be a critical companion diagnostic test before prescription of a targeted therapy. Each method for detection of these mutations is associated with an analytic sensitivity that is a function of the percentage of tumor cells present in the specimen. Currently, tumor cell percentage is visually estimated resulting in an ordinal and highly variant result for a...

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Identifiers

PMID: 24162261
DOI: 10.1097/PAI.0b013e318299a1f6
PMCID: PMC3999345

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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