Article
The genetics of the alternative pathway of complement in the pathogenesis of HELLP syndrome.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - 1 Nov 2012
Crovetto Francesca, Borsa Nicolò, Acaia Barbara, Nishimura Carla, Frees Kathy, Smith Richard J H, Peyvandi Flora, Palla Roberta, Cugno Massimo, Tedeschi Silvana, Castorina Pierangela, Somigliana Edgardo, Ardissino Gianluigi, Fedele Luigi
Abstract excerpt
OBJECTIVE: Recent preliminary evidence suggests that gene mutations in the alternative pathway of complement may play a crucial role in the pathogenesis of HELLP syndrome. To verify this hypothesis, a consecutive series of women who developed the syndrome was screened for variants in alternative pathway genes. METHODS: The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement...
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