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Article

A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.

The Journal of biological chemistry - 6 Jul 2012

Kilkenny Mairi L, De Piccoli Giacomo, Perera Rajika L, Labib Karim, Pellegrini Luca

Abstract excerpt

The DNA polymerase α-primase complex forms an essential part of the eukaryotic replisome. The catalytic subunits of primase and pol α synthesize composite RNA-DNA primers that initiate the leading and lagging DNA strands at replication forks. The physical basis and physiological significance of tethering primase to the eukaryotic replisome via pol α remain poorly characterized. We have identified a short...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22593576
DOI: 10.1074/jbc.M112.368951
PMCID: PMC3390648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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