Article
Using a priori knowledge to align sequencing reads to their exact genomic position.
Nucleic acids research - 1 Sept 2012
Böttcher René, Amberg Ronny, Ruzius F P, Guryev V, Verhaegh Wim F J, Beyerlein Peter, van der Zaag P J
Abstract excerpt
The use of a priori knowledge in the alignment of targeted sequencing data is investigated using computational experiments. Adapting a Needleman-Wunsch algorithm to incorporate the genomic position information from the targeted capture, we demonstrate that alignment can be done to just the target region of interest. When in addition use is made of direct string comparison, an improvement of up to a factor of 8 in...
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