Article
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.
ACS chemical biology - 17 Aug 2012
Stanley Sarah A, Grant Sarah Schmidt, Kawate Tomohiko, Iwase Noriaki, Shimizu Motohisa, Wivagg Carl, Silvis Melanie, Kazyanskaya Edward, Aquadro John, Golas Aaron, Fitzgerald Michael, Dai Huanqin, Zhang Lixin, Hung Deborah T
Abstract excerpt
Despite the urgent need for new antitubercular drugs, few are on the horizon. To combat the problem of emerging drug resistance, structurally unique chemical entities that inhibit new targets will be required. Here we describe our investigations using whole cell screening of a diverse collection of small molecules as a methodology for identifying novel inhibitors that target new pathways for Mycobacterium...
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