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Article

Genetic variants in the PI3K/PTEN/AKT/mTOR pathway predict head and neck cancer patient second primary tumor/recurrence risk and response to retinoid chemoprevention.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2012

Hildebrandt Michelle A T, Lippman Scott M, Etzel Carol J, Kim Edward, Lee J Jack, Khuri Fadlo R, Spitz Margaret R, Lotan Reuben, Hong Waun Ki, Wu Xifeng

Abstract excerpt

PURPOSE: The development of second primary tumors (SPT) or recurrence alters prognosis for curatively treated head and neck squamous cell carcinoma (HNSCC) patients. The 13-cis-Retinoic acid (13-cRA) has been tested as a chemoprevention agent in clinical trials with mixed results. Therefore, we investigated whether genetic variants in the PI3K/PTEN/AKT/mTOR pathway could serve as biomarkers to identify which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Recurrence, Local

Share to Neoplasms, Second Primary

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Source

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Identifiers

PMID: 22577058
DOI: 10.1158/1078-0432.CCR-11-3271
PMCID: PMC3404728

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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