Article
Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
Carcinogenesis - 1 Oct 2010
Wang Jianming, Lippman Scott M, Lee J Jack, Yang Hushan, Khuri Fadlo R, Kim Edward, Lin Jie, Chang David W, Lotan Reuben, Hong Waun K, Wu Xifeng
Abstract excerpt
Curatively treated patients with early-stage head and neck squamous cell carcinoma (HNSCC) are at high risks for second primary tumor (SPT) and recurrence. The regulator of G-protein signaling (RGS) is important in essential signaling transduction and cellular activities. We hypothesize that genetic variations of RGS may modulate the risk of SPT/recurrence in patients with early-stage HNSCC. In a nested...
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