Article
Protein Z polymorphisms associated with vaso-occlusive crisis in young sickle cell disease patients.
Annals of hematology - 1 Aug 2012
Mahdi Najat, Abu-Hijleh Tala M, Abu-Hijleh Farah M, Sater Mai S, Al-Ola Khadija, Almawi Wassim Y
Abstract excerpt
We investigated the association of protein Z (PZ) promoter (rs3024718, rs3024719, and rs3024731) and intron (rs3024735; G79A) SNPs with sickle cell disease (SCD) vaso-occlusive crisis (VOC). Study subjects included 239 SCD patients with VOC and 138 pain-free SCD control patients. PZ genotyping was done by allelic discrimination (real-time PCR) assays. The minor allele frequency of rs3024718 (P=0.03), ...