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Article

Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils.

Archives of biochemistry and biophysics - 15 Jul 2012

Yu Wen-Bo, Jiang Teng, Lan Dan-Mei, Lu Jia-Hong, Yue Zhen-Yu, Wang Jian, Zhou Ping

Abstract excerpt

The aggregation of alpha-synuclein (AS) is pivotally implicated in the development of Parkinson's disease (PD), inhibiting this process might be effective in treating PD. Here, by using circular dichroism spectroscopy, thioflavin T fluorescence, and atomic force microscopy, we found that trehalose at low concentration disaggregates preformed A53T AS protofibrils and fibrils into small aggregates or even random...

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PMID: 22575388
DOI: 10.1016/j.abb.2012.04.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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