Article
Role of stem cells in human uterine leiomyoma growth.
PloS one - 1 Jan 2012
Ono Masanori, Qiang Wenan, Serna Vanida Ann, Yin Ping, Coon John S, Navarro Antonia, Monsivais Diana, Kakinuma Toshiyuki, Dyson Matthew, Druschitz Stacy, Unno Kenji, Kurita Takeshi, Bulun Serdar E
Abstract excerpt
BACKGROUND: Uterine leiomyoma is the most common benign tumor in reproductive-age women. Each leiomyoma is thought to be a benign monoclonal tumor arising from a single transformed myometrial smooth muscle cell; however, it is not known what leiomyoma cell type is responsible for tumor growth. Thus, we tested the hypothesis that a distinct stem/reservoir cell-enriched population, designated as the...
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