Article
Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells.
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2007
Ono Masanori, Maruyama Tetsuo, Masuda Hirotaka, Kajitani Takashi, Nagashima Takashi, Arase Toru, Ito Mamoru, Ohta Kuniaki, Uchida Hiroshi, Asada Hironori, Yoshimura Yasunori, Okano Hideyuki, Matsuzaki Yumi
Abstract excerpt
Over the course of pregnancy, the human uterus undergoes a 500- to 1,000-fold increase in volume and a 24-fold increase in weight. The uterine smooth muscle layer or myometrium is remodeled, and both cell hypertrophy and hyperplasia are evident. The origin of the new smooth muscle cells, however, is unclear. They may arise from existing smooth muscle cells, or they may be the product of stem cell differentiation....
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