Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs.

PLoS pathogens - 1 Jan 2012

Kaelber Jason T, Demogines Ann, Harbison Carole E, Allison Andrew B, Goodman Laura B, Ortega Alicia N, Sawyer Sara L, Parrish Colin R

Abstract excerpt

Parvoviruses exploit transferrin receptor type-1 (TfR) for cellular entry in carnivores, and specific interactions are key to control of host range. We show that several key mutations acquired by TfR during the evolution of Caniforms (dogs and related species) modified the interactions with parvovirus capsids by reducing the level of binding. These data, along with signatures of positive selection in the TFRC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsid
Share to Capsid Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dog Diseases

Share to Parvoviridae Infections

Share to Parvovirus, Canine

Share to Receptors, Transferrin

Share to Receptors, Virus

Share to Transferrin

Source

Open in PubMed Open full text

Identifiers

PMID: 22570610
DOI: 10.1371/journal.ppat.1002666
PMCID: PMC3342950

Genes

TFRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolutionary reconstructions of the transferrin receptor of Caniforms supports canine parvovirus being a re-emerged and not a novel pathogen in dogs.PMID 22570610Read ↗

Role of Multiple Hosts in the Cross-Species Transmission and Emergence of a Pandemic ParvovirusSemantic proximity Read ↗

Transferrin receptor binds virus capsid with dynamic motionSemantic proximity Read ↗

Viral Capsid, Antibody, and Receptor Interactions: Experimental Analysis of the Antibody Escape Evolution of Canine Parvovirus.Semantic proximity Read ↗

Complex and Dynamic Interactions between Parvovirus Capsids, Transferrin Receptors, and Antibodies Control Cell Infection and Host Range.Semantic proximity Read ↗

Residues 27T and 297A in VP2 contribute to the enhanced replication and pathogenicity of raccoon dog parvovirus.Semantic proximity Read ↗

Limited Intrahost Diversity and Background Evolution Accompany 40 Years of Canine Parvovirus Host Adaptation and Spread.Semantic proximity Read ↗

Limited intra-host diversity and background evolution accompany 40 years of canine parvovirus host adaptation and spreadSemantic proximity Read ↗

Viral capsid, antibody, and receptor interactions: experimental analysis of the antibody escape evolution of canine parvovirusSemantic proximity Read ↗

The role of evolutionary intermediates in the host adaptation of canine parvovirus.Semantic proximity Read ↗

Dual host-virus arms races shape an essential housekeeping protein.Semantic proximity Read ↗

Distinct evolutionary patterns of endemic and emerging parvoviruses, and the origin of a new pandemic virusSemantic proximity Read ↗

Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.