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Article

Residues 27T and 297A in VP2 contribute to the enhanced replication and pathogenicity of raccoon dog parvovirus.

Journal of virology - 23 Oct 2025

Xu Liwen, Cao Wenyu, Liu Yawen, Hu Bo, Zhang Chengqi, Li Shuangshuang, Liu Jiajia, Fu Jianhai, Zhang Zichuang, Sun Yajie, Zhao Guanyu, Deng Xiaoyu, Lu Rongguang, Bai Xue

Abstract excerpt

Raccoon dog parvovirus (RDPV) is a highly contagious pathogen causing severe hemorrhagic enteritis that is fatal in young raccoon dogs. Since 2016, epidemiological investigations have documented recurrent outbreaks of RDPV, exhibiting heightened virulence; however, the molecular mechanisms driving this increased pathogenicity remain poorly understood. In this study, an alignment of 67 complete RDPV sequences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40910686
DOI: 10.1128/jvi.01012-25
PMCID: PMC12548415

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