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Article

Dual host-virus arms races shape an essential housekeeping protein.

PLoS biology - 1 Jan 2013

Demogines Ann, Abraham Jonathan, Choe Hyeryun, Farzan Michael, Sawyer Sara L

Abstract excerpt

Transferrin Receptor (TfR1) is the cell-surface receptor that regulates iron uptake into cells, a process that is fundamental to life. However, TfR1 also facilitates the cellular entry of multiple mammalian viruses. We use evolutionary and functional analyses of TfR1 in the rodent clade, where tw...

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Identifiers

PMID: 23723737
DOI: 10.1371/journal.pbio.1001571
PMCID: PMC3665890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23723737-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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