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Article

Transferrin receptor binds virus capsid with dynamic motion

23 Sept 2019

Abstract excerpt

Canine parvovirus (CPV) is an important pathogen causing severe diseases in dogs, including acute hemorrhagic enteritis, myocarditis, and cerebellar disease. Cross-species transmission of CPV occurs as a result of mutations on the viral capsid surface that alter the species-specific binding to the host receptor, transferrin receptor type-1 (TfR). The interaction between CPV and TfR has been extensively studied,...

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PMID: 31548398
DOI: 10.1073/pnas.1904918116

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