Article
Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival.
The American journal of pathology - 1 Mar 2013
Lake Sarah L, Damato Bertil E, Kalirai Helen, Dodson Andrew R, Taktak Azzam F G, Lloyd Bryony H, Coupland Sarah E
Abstract excerpt
Metastatic death from uveal melanoma occurs almost exclusively with tumors showing monosomy of chromosome 3. However, approximately 5% of patients with a disomy 3 uveal melanoma develop metastases, and a further 5% of monosomy 3 uveal melanoma patients exhibit disease-free survival for >5 years. In the present study, whole-genome microarrays were used to interrogate four clinically well-defined subgroups of uveal...
Topics
- Aged
- DNA Copy Number Variations
- Enkephalins
- Female
- Gene Amplification
- Genes, Neoplasm
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Male
- Melanoma
- Membrane Proteins
- Middle Aged