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Article

Prenatal synthetic glucocorticoid treatment changes DNA methylation states in male organ systems: multigenerational effects.

Endocrinology - 1 Jul 2012

Crudo Ariann, Petropoulos Sophie, Moisiadis Vasilis G, Iqbal Majid, Kostaki Alisa, Machnes Ziv, Szyf Moshe, Matthews Stephen G

Abstract excerpt

Prenatal synthetic glucocorticoids (sGC) are administered to pregnant women at risk of delivering preterm, approximately 10% of all pregnancies. Animal studies have demonstrated that offspring exposed to elevated glucocorticoids, either by administration of sGC or as a result of maternal stress, are at increased risk of developing behavioral, endocrine, and metabolic abnormalities. DNA methylation is a covalent...

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Identifiers

PMID: 22564977
DOI: 10.1210/en.2011-2160
PMCID: PMC3422463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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