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Article

Betamethasone administration during pregnancy is associated with placental epigenetic changes with implications for inflammation

26 Aug 2021

Abstract excerpt

BACKGROUND: Glucocorticoids (GCs) play a pivotal role in fetal programming. Antenatal treatment with synthetic GCs (sGCs) in individuals in danger of preterm labor is common practice. Adverse short- and long-term effects of antenatal sGCs have been reported, but their effects on placental epigenetic characteristics have never been systematically studied in humans. RESULTS: We tested the association between...

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PMID: 34446099
DOI: 10.1186/s13148-021-01153-y

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