Article
Antenatal Synthetic Glucocorticoid Exposure at Human Therapeutic Equivalent Doses Predisposes Middle-Age Male Offspring Baboons to an Obese Phenotype That Emerges With Aging.
Reproductive sciences (Thousand Oaks, Calif.) - 1 May 2019
Huber Hillary F, Kuo Anderson H, Li Cun, Jenkins Susan L, Gerow Kenneth G, Clarke Geoffrey D, Nathanielsz Peter W
Abstract excerpt
INTRODUCTION: Women threatening premature delivery receive synthetic glucocorticoids (sGC) to accelerate fetal lung maturation, reducing neonatal mortality and morbidity. Few investigations have explored potential long-term offspring side effects. We previously reported increased pericardial fat and liver lipids in 10-year-old (human equivalent 40 years) male baboons exposed to 3 antenatal sGC courses. We...
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