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Article

Multigenerational programming in the glucocorticoid programmed rat is associated with generation-specific and parent of origin effects

1 Nov 2011

Abstract excerpt

Exposure to an adverse early life environment is associated with increased cardio-metabolic disease risk, a phenomenon termed "programming." The effects of this are not limited to the exposed first (F1) generation but can be transmissible to a second generation (F2) through male and female lines. Using a three generation animal model of programming by initial prenatal glucocorticoid overexposure we have...

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PMID: 22086116
DOI: 10.4161/epi.6.11.17942

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