Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells.

doi:10.1016/j.intimp.2012.04.010

Article

Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells.

International immunopharmacology - 1 Jul 2012

Gambari Roberto, Borgatti Monica, Lampronti Ilaria, Fabbri Enrica, Brognara Eleonora, Bianchi Nicoletta, Piccagli Laura, Yuen Marcus Chun-Wah, Kan Chi-Wai, Hau Desmond Kwok-Po, Fong Wang-Fun, Wong Wai-Yeung, Wong Raymond Siu-Ming, Chui Chung-Hin

Abstract excerpt

Corilagin (beta-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose), a gallotannin identified in several plants, including Phyllanthus urinaria, has been shown to exhibit versatile medicinal activities. As far as possible anti-inflammatory effects of corilagin, only few reports are available, and the potential use of corilagin as possible therapeutic molecule for cystic fibrosis has not been evaluated. In the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells.

Abstract excerpt

Topics

Related research