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Article

NF-κB Mediates Up-regulation of CFTR Gene Expression in Calu-3 Cells by Interleukin-1β

1 Mar 2001

Abstract excerpt

Inflammation of the airways is a major feature of the inherited disease cystic fibrosis. Previous studies have shown that the pro-inflammatory cytokines tumor necrosis factor alpha and interferon gamma reduce the expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene (CFTR) in HT-29 and T84 cells by acting post-transcriptionally. We have investigated the effect of the pro-inflammatory...

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PMID: 11114294
DOI: 10.1074/jbc.m006636200

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