Article
Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways.
Biochemical pharmacology - 15 Jun 2007
Verhaeghe Catherine, Remouchamps Caroline, Hennuy Benoît, Vanderplasschen Alain, Chariot Alain, Tabruyn Sebastien P, Oury Cecile, Bours Vincent
Abstract excerpt
In cystic fibrosis (CF) patients, pulmonary inflammation is a major cause of morbidity and mortality and may precede bacterial colonization. The aim of the present study was to investigate the molecular mechanisms underlying intrinsic inflammation in cystic fibrosis airways. Using different cystic fibrosis cell models, we first demonstrated that, beside a high constitutive nuclear factor of kappaB (NF-kappaB)...
Topics
- Cell Line, Transformed
- Chemokine CXCL1
- Chemokine CXCL2
- Chemokines, CXC
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Enzyme-Linked Immunosorbent Assay
- Extracellular Signal-Regulated MAP Kinases
- Fibroblast Growth Factor 2
- Gene Expression
- Genes, Reporter
- HeLa Cells