Article
Generational association studies of dopaminergic genes in reward deficiency syndrome (RDS) subjects: selecting appropriate phenotypes for reward dependence behaviors.
International journal of environmental research and public health - 1 Dec 2011
Blum Kenneth, Chen Amanda L C, Oscar-Berman Marlene, Chen Thomas J H, Lubar Joel, White Nancy, Lubar Judith, Bowirrat Abdalla, Braverman Eric, Schoolfield John, Waite Roger L, Downs Bernard W, Madigan Margaret, Comings David E, Davis Caroline, Kerner Mallory M, Knopf Jennifer, Palomo Tomas, Giordano John J, Morse Siobhan A, Fornari Frank, Barh Debmalya, Femino John, Bailey John A
Abstract excerpt
UNLABELLED: Abnormal behaviors involving dopaminergic gene polymorphisms often reflect an insufficiency of usual feelings of satisfaction, or Reward Deficiency Syndrome (RDS). RDS results from a dysfunction in the "brain reward cascade," a complex interaction among neurotransmitters (primarily dopaminergic and opioidergic). Individuals with a family history of alcoholism or other addictions may be born with a...
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