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Article

Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity.

Human molecular genetics - 15 Nov 2010

Ferri Alberto, Fiorenzo Paolo, Nencini Monica, Cozzolino Mauro, Pesaresi Maria Grazia, Valle Cristiana, Sepe Sara, Moreno Sandra, Carrì Maria Teresa

Abstract excerpt

Vulnerability of motoneurons in amyotrophic lateral sclerosis (ALS) arises from a combination of several mechanisms, including protein misfolding and aggregation, mitochondrial dysfunction and oxidative damage. Protein aggregates are found in motoneurons in models for ALS linked to a mutation in the gene coding for Cu,Zn superoxide dismutase (SOD1) and in ALS patients as well. Aggregation of mutant SOD1 in the...

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Source

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Identifiers

PMID: 20829229
DOI: 10.1093/hmg/ddq383
PMCID: PMC3298854

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity.PMID 20829229Read ↗

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