Article
The TT genotype of methylenetetrahydrofolate reductase 677C>T polymorphism increases the susceptibility to pediatric ischemic stroke: meta-analysis of the 822 cases and 1,552 controls.
Molecular biology reports - 1 Aug 2012
Sarecka-Hujar Beata, Kopyta Ilona, Pienczk-Reclawowicz Karolina, Reclawowicz Daniel, Emich-Widera Ewa, Pilarska Ewa
Abstract excerpt
The 677C>T polymorphism within methylenetetrahydrofolate reductase (MTHFR) gene is related to an elevated level of homocysteine. Thus it may be considered as a genetic risk factor in ischemic stroke. Apparently studies of this type of polymorphism in childhood stroke have shown conflicting results. We performed meta-analysis of all the data that are available in relation with MTHFR polymorphism and the risk of...
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