Is the 1298A>C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis.

doi:10.1007/s10238-018-0489-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Is the 1298A>C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis.

Clinical and experimental medicine - 1 Aug 2018

Sarecka-Hujar Beata, Kopyta Ilona, Skrzypek Michal

Abstract excerpt

An elevated level of homocysteine is a risk factor for vascular diseases, brain atrophy and several other disorders. The 1298A>C polymorphism (rs1801131) leads to mildly decreased MTHFR activity. Previously, it was observed that the MTHFR 1298A>C polymorphism in combined analysis with the MTHFR 677C>T polymorphism increases homocysteine levels. However, conflicting results on its relation to ischaemic stroke in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Ischemia

Share to Child

Share to Gene Expression

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Odds Ratio

Share to Risk Factors

Share to Stroke

Source

Open in PubMed

Identifiers

PMID: 29396624
DOI: 10.1007/s10238-018-0489-2

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is the 1298A>C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis.PMID 29396624Read ↗

The TT genotype of methylenetetrahydrofolate reductase 677C>T polymorphism increases the susceptibility to pediatric ischemic stroke: meta-analysis of the 822 cases and 1,552 controls.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene A1298C polymorphism in pediatric stroke--case-control and family-based study.Semantic proximity Read ↗

Relevance of Plasma Homocysteine and Methylenetetrahydrofolate Reductase 677TT Genotype in Sickle Cell Disease: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Genetic risk factors for arterial ischemic stroke in children: a possible MTHFR and eNOS gene-gene interplay?Semantic proximity Read ↗

A meta-analysis of the relationship between MTHFR gene A1298C polymorphism and the risk of adult stroke.Semantic proximity Read ↗

The rs10757278 Polymorphism of the 9p21.3 Locus in Children with Arterial Ischemic Stroke: A Family-Based and Case-Control Study.Semantic proximity Read ↗

Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status.Semantic proximity Read ↗

Common mutations at the homocysteine metabolism pathway and pediatric stroke.Semantic proximity Read ↗

The role of genetic risk factors in arterial ischemic stroke in pediatric and adult patients: a critical review.Semantic proximity Read ↗

The effect of polymorphisms of MTHFR C677T, A1298C, MS A2756G and CBS 844ins68bp on plasma total homocysteine level and the risk of ischemic stroke in Thai children.Semantic proximity Read ↗

Association of the A1298C polymorphism in MTHFR gene with ischemic stroke.Semantic proximity Read ↗

Association between 5,10-Methylenetetrahydrofolate Reductase C677T Gene Polymorphism and Risk of Ischemic Stroke: A Meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.