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Article

Methylenetetrahydrofolate reductase gene A1298C polymorphism in pediatric stroke--case-control and family-based study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jan 2015

Balcerzyk Anna, Niemiec Paweł, Kopyta Ilona, Emich-Widera Ewa, Pilarska Ewa, Pienczk-Ręcławowicz Karolina, Kaciński Marek, Wendorff Janusz, Żak Iwona

Abstract excerpt

Moderate hyperhomocysteinemia is one of the risk factors of pediatric stroke. Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme, which regulates homocysteine metabolism, and some polymorphisms of gene encoding this enzyme are associated with a decreased activity of the enzyme. The aim of the study was to assess an association between the A1298C polymorphism and pediatric stroke. We also evaluated...

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Identifiers

PMID: 25440348
DOI: 10.1016/j.jstrokecerebrovasdis.2014.07.034

Genes

MTHFR

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