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Article

Proarrhythmic defects in Timothy syndrome require calmodulin kinase II.

Circulation - 25 Nov 2008

Thiel William H, Chen Biyi, Hund Thomas J, Koval Olha M, Purohit Anil, Song Long-Sheng, Mohler Peter J, Anderson Mark E

Abstract excerpt

BACKGROUND: Timothy syndrome (TS) is a disease of excessive cellular Ca(2+) entry and life-threatening arrhythmias caused by a mutation in the primary cardiac L-type Ca(2+) channel (Ca(V)1.2). The TS mutation causes loss of normal voltage-dependent inactivation of Ca(V)1.2 current (I(Ca)). During...

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Identifiers

PMID: 19001023
DOI: 10.1161/CIRCULATIONAHA.108.788067
PMCID: PMC3226825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19001023-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Proarrhythmic defects in Timothy syndrome require calmodulin kinase II.PMID 19001023Read ↗

Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivationSemantic proximity Read ↗

L-type Ca2+ channel function during Timothy syndrome.Semantic proximity Read ↗

Current updates on arrhythmia within Timothy syndrome: genetics, mechanisms and therapeutics.Semantic proximity Read ↗

The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channels.Semantic proximity Read ↗

Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations.Semantic proximity Read ↗

Unexpected impairment of INa underpins reentrant arrhythmias in a knock-in swine model of Timothy syndromeSemantic proximity Read ↗

CaV1.2 channelopathic mutations evoke diverse pathophysiological mechanisms.Semantic proximity Read ↗

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome.Semantic proximity Read ↗

Ca <sub>V</sub> 1.2 channelopathic mutations evoke diverse pathophysiological mechanismsSemantic proximity Read ↗

Unexpected Impairment of INa current Underpins Reentrant Arrhythmias in a Knock-in Swine Model of Timothy SyndromeSemantic proximity Read ↗

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