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Article

Stimulation of vesicular monoamine transporter 2 activity by DJ-1 in SH-SY5Y cells.

Biochemical and biophysical research communications - 18 May 2012

Ishikawa Shizuma, Tanaka Yuki, Takahashi-Niki Kazuko, Niki Takeshi, Ariga Hiroyoshi, Iguchi-Ariga Sanae M M

Abstract excerpt

Loss-of-functional mutation in the DJ-1 gene causes a subset of familial Parkinson's disease. The mechanism underlying DJ-1-related selective vulnerability in the dopaminergic pathway is, however, not known. Dopamine is synthesized by two enzymes and then packed into synaptic vesicles by vesicular monoamine transporter 2 (VMAT2). In this study, we found that knockdown of DJ-1 expression reduced the levels of mRNA...

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Identifiers

PMID: 22554508
DOI: 10.1016/j.bbrc.2012.04.095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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