Article
DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals.
Proceedings of the National Academy of Sciences of the United States of America - 13 Feb 2018
Kyung Jae Won, Kim Jin-Mo, Lee Wongyoung, Ha Tae-Young, Cha Seon-Heui, Chung Kyung-Hwun, Choi Dong-Joo, Jou Ilo, Song Woo Keun, Joe Eun-Hye, Kim Sung Hyun, Park Sang Myun
Abstract excerpt
Mutations in DJ-1 (PARK7) are a known cause of early-onset autosomal recessive Parkinson's disease (PD). Accumulating evidence indicates that abnormalities of synaptic vesicle trafficking underlie the pathophysiological mechanism of PD. In the present study, we explored whether DJ-1 is involved in CNS synaptic function. DJ-1 deficiency impaired synaptic vesicle endocytosis and reavailability without inducing...
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