Structural basis for sigma factor mimicry in the general stress response of Alphaproteobacteria.

Abstract excerpt

Reprogramming gene expression is an essential component of adaptation to changing environmental conditions. In bacteria, a widespread mechanism involves alternative sigma factors that redirect transcription toward specific regulons. The activity of sigma factors is often regulated through sequestration by cognate anti-sigma factors; however, for most systems, it is not known how the activity of the anti-sigma...

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• Alphaproteobacteria
• DNA-Directed RNA Polymerases
• Hydrophobic and Hydrophilic Interactions
• Molecular Mimicry
• Nuclear Magnetic Resonance, Biomolecular